Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system and the most common disabling neurological disorder in young adults1,2. It is clinically characterized by a variety of neurological signs and symptoms which are attributed to white matter lesions. Those lesions are disseminated in time and space. Clinical signs may appear in sudden attacks or be insidious and progressive3,4. The diagnosis of pediatric MS has been largely overlooked by pediatricians and pediatric neurologists5,6, who have long regarded it as a rare disease.